Prevention of preeclampsia with calcium supplementation and its relation with L-arginine: citric oxide pathway
Braz. j. med. biol. res
;
29(6): 731-41, jun. 1996. tab
Artigo
em Inglês
| LILACS
| ID: lil-181407
ABSTRACT
Pregnancy-induced hypertension (PIH) remains a common cause of maternal and fetal morbidity and mortality. During the past 7 years, some progress has been made in the prevention of PIH. Specifically, clinical studies have shown that supplementation with calcium can significantly reduce the frequency of PIH, especially in populations with a low calcium intake. We have suggested that, in such a population, calcium supplementation is a safe and effective measure for reducing the incidence of PIH. Calcium supplementation reduces the risk of PIH by maintaining the serum ionized calcium level which is crucial for the production of endothelial nitric oxide, the increased generation of which maintains the vasodilatation that is characteristic of normal pregnancy. In PIH there is an impaired nitric oxide synthesis and cyclic GMP production.
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Índice:
LILACS (Américas)
Assunto principal:
Pré-Eclâmpsia
/
Complicações Cardiovasculares na Gravidez
/
Alimentos Fortificados
/
Cálcio
/
Hipertensão
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1996
Tipo de documento:
Artigo
/
Congresso e conferência
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