Asymptomatic Leishmania chagasi infection in relatives and neighbors of patients with visceral leishmaniasis
Mem. Inst. Oswaldo Cruz
;
92(1): 15-20, Jan.-Feb. 1997. tab
Artigo
em Inglês
| LILACS
| ID: lil-182847
ABSTRACT
The frequency of asymptomatic infection among relatives and neighbors of cases of visceral leishmaniasis (VL) was compared and characterization of the immunological response in these subjects was performed. Cases were from a new endemic area, close to the beach and near Salvador, capital of the state of Bahia, Brazil. The characterization of asymptomatic infection was made using a skin reaction test and detection of antibody to Leishmania chagasi by the ELISA test. To characterize the immunological response of these subjects with asymptomatic L. chagasi infection the cytokines profile and the lymphoproliferative response were determined after stimulation of lymphocytes by L.chagasi antigen. There was no difference in the frequency of L. chagasi infection in relatives (45 per cent) and in neighbors (27 per cent) of cases of VL (P>0.05). The immunological response from these subjects was characterized by high production of IFN-µ and a low production of IL-10 and a good lymphoproliferative response to L.chagasi antigen.
Texto completo:
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Índice:
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Assunto principal:
Leishmania donovani
/
Portador Sadio
/
Leishmaniose Visceral
/
Antígenos de Protozoários
Limite:
Humanos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
1997
Tipo de documento:
Artigo
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