Laminin-binding proteins in EJ-ras-transformed fibroblasts
Braz. j. med. biol. res
;
29(9): 1141-9, Sept. 1996.
Artigo
em Inglês
| LILACS
| ID: lil-186124
ABSTRACT
Malignant transformation is accompanied by changes in cell-matrix interations. Upon transfection with EJ-ras oncogene, transformed fibroblasts, acquired a migratory phenotype towards laminin-1. The increase in integrin expression was responsible for the migratory activity of transformed fibroblasts. In addition alpha(6)beta(1) integrins, both galectin-3 and an unidentified laminin-binding polypeptide had their expression pattern altered upon transformation. Here, we review these two classes of laminin-binding proteins and their possible roles in cell-laminin interactions.
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Índice:
LILACS (Américas)
Assunto principal:
Neoplasias Mamárias Animais
/
Genes ras
/
Laminina
/
Fibroblastos
/
Lectinas
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1996
Tipo de documento:
Artigo
/
Congresso e conferência
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