The role of collagen in hematopoiesis
Braz. j. med. biol. res
;
29(9): 1201-7, Sept. 1996. tab
Artigo
em Inglês
| LILACS
| ID: lil-186127
RESUMO
Several types of collagen, including types I, III, IV, V and VI, are produced by bone marrow stromal cells. Current information indicates that changes in collagen production result in profound alterations in the capacity of hematopoietic precursors to proliferate and differentiate. Although not definitively established, collagen molecules may be involved in the establishment and conformation of the stroma-associated extracellular matrix and/or in adhesive interactions with progenitor cells. The dynamic role of collagen in hematopoiesis is indicated by the observation that collagen production and processing are regulated by several factors such as glucocorticoids, cytokines, collagenases and collagenase-inhibitory proteins.
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Índice:
LILACS (Américas)
Assunto principal:
Medula Óssea
/
Técnicas In Vitro
/
Fator Estimulador de Colônias de Granulócitos
/
Fator de Crescimento Transformador beta
/
Colágeno
/
Colagenases
/
Matriz Extracelular
/
Hematopoese
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1996
Tipo de documento:
Artigo
/
Congresso e conferência
/
Documento de projeto
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