Molecular and immunological characteristics in the pathogenesis of tropical spastic paraparesis - HTLV-1 - associated myelopathy (TSP/HAM)
Ciênc. cult. (Säo Paulo)
;
48(5/6): 351-8, Sept.-Dec. 1996. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-186335
RESUMO
The approach taken by my group to determine viral markers associated with human T-cell leukemia virus type 1 (HTLV-1) disease induction was to compare viral genomes and host immune responses of HTLV-1 infected patients from one geographical area with a significant incidence rate of TSP/HAM. These studies showed that TSP/HAM patients have higher titers of antibodies against viral antigens and higher proviral and viral load as compared to asymptomatic carriers and adult T-cell leukemia (ATL) patients. Some mutations in the envelope glycoprotein gp62 gene were restricted to Tumaco isolates suggesting that a process of genetic drift acts as a force to maintain those mutations in the population. The mechanism by which HTLV-1 induces TSP/HAM is still unknown; however, there is strong evidence focusing on the problem of pathogenesis of TSP/HAM as an autoimmune process produced via molecular mimicry.
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Índice:
LILACS (Américas)
Assunto principal:
Vírus Linfotrópico T Tipo 1 Humano
/
Paraparesia Espástica Tropical
/
Anticorpos Antivirais
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Ciênc. cult. (Säo Paulo)
Assunto da revista:
Ciência
Ano de publicação:
1996
Tipo de documento:
Artigo
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