DNA damage induced by secondary lipid oxidation products

RESUMO

Lipid peroxidation in cell membranes has been associated with a wide variety of deleterious processes leading to cellular damage, cancer, inflammation and aging. Aldehydes formed as secondary lipid oxidation products have been suggested to be more toxic than lipid hydroperoxides. Heve we summarize data on DNA damage induced by reactive aldehydes. While the ultimate mechanisms responsible for the aging process and tumorigenesis are obscure, there is growing evidence that aldehydes produced as secondary lipid peroxidation products play a key role in the chromosomal damage associated with these processes.