Influence of the pituitary gland on the immune response in young rats
Acta physiol. pharmacol. ther. latinoam
;
46(3): 169-76, 1996. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-187281
RESUMO
The response of hypophysectomized (HYPOX) and sham-operated (S-HYPOX) female and male Wistar young rats (8 weeks old) to antigenic stimulation was compared. Humoral antigenic responses against hemocyanin were measured by ELISA. [3H]thyimidine incorporation into cultured splen cells was used to determine proliferative response to concanavalin A (ConA) or antigenic stimulation. Anti-hemocyanin serum titers in the HYPOX animals was about half of that observed in control S-HYPOX rats. Similarly, the cellular proliferative response was significantly decreased in HYPOX animals when compared to S-HYPOX rats; the blastogenic response to hemocyanin in UC rats (which did not receive the antigen injection) was close to zero. S-HYPOX control rats responded to direct ConA stimulation as UC controls. Body weight and the weight of pituitary target organs (adrenal, thyroid, ovary and testes) was about 1/4 of that of controls. Hypophysectomy also resulted in a striking reduction in spleen weight. These results indicate that the pituitary gland is involved in cellular and humoral immune regulation in young rats.
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Índice:
LILACS (Américas)
Assunto principal:
Hipófise
/
Hemocianinas
/
Imunização
/
Hipofisectomia
Limite:
Animais
Idioma:
Inglês
Revista:
Acta physiol. pharmacol. ther. latinoam
Assunto da revista:
Farmacologia
/
Fisiologia
/
Terapêutica
Ano de publicação:
1996
Tipo de documento:
Artigo
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