Pinealectomy attenuates the effect of restraint on plus maze exploration in rats
Braz. j. med. biol. res
; 29(8): 1031-4, Aug. 1996. graf
Article
em En
| LILACS
| ID: lil-187374
Biblioteca responsável:
BR1.1
ABSTRACT
To investigate a possible stress modulation role of the pineal gland, male Wistar albino rats (200-250 g) were submitted to pinealectomy and divided into four groups one week after surgery i) sham-operated unrestrained animals (N = 14); ii) pinealectomized unrestrained animals (N = 22); iii) sham-operated animals submitted to 2 h of restraint (N = 52); iv) pinealectomized animals submitted to 2 h of restraint (N = 56). Twenty-four hours later the animals were tested in the elevated plus maze for 5 min. Pinealectomized rats submitted to restraint explored the open arms of the maze to a greater extent than sham-operated restrained rats (mean percent of open arm entries = 26.4 ñ 2.3 vs 18.0 ñ 2.1, mean percent of time spent in the open arms = 11.8 ñ 2.1 vs 6.8 ñ 1.2). Pinealectomized animals not submitted to restraint showed no difference in maze exploration when compared to sham-operated rats (mean percent of open arm entries = 29.3 ñ 3.8 vs 31.1 ñ 5.8, mean percent of time spent in the open arms = 8.8 ñ 1.8 vs 12.5 ñ 2.2). The results, therefore, suggest that the pineal gland may play a modulatory role in the behavioral consequences of stress.
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Índice:
LILACS
Assunto principal:
Glândula Pineal
/
Hormônio Adrenocorticotrópico
/
Comportamento Exploratório
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1996
Tipo de documento:
Article