Does plasma ANP participate in natriuresis induced by alpha-MSH?
Braz. j. med. biol. res
;
30(4): 459-63, Apr. 1997. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-191383
ABSTRACT
Alpha-Melanocyte-stimulating hormone (alpha-MSH;0.6 and 3 nmol) microinjected into the anteroventral region of the third ventricle (AV3V) induced a significant increase in diuresis without modifying natriuresis or kaliuresis. Intraperitoneal (ip) injection of alpha-MSH (3 and 9.6 nmol) induced a significant increase urinary sodium, potassium and water excretion. Intraperitoneal (3 and 4.8 nmol) or iv (3 and 9.6 nmol) administration of alpha-MSH did not induce any significant changes in plasma atrial natriuretic peptide (ANP), suggesting that the natriuresis, kaliuresis and diuresis induced by the systemic action of alpha-MSH can be dissociated from the increase in plasma ANP. These preliminary results suggest that alpha-MSH may be involved in a gamma-MSH-independent mechanism of regulation of hydromineral metabolism.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Alfa-MSH
/
Ventrículos Cerebrais
/
Fator Natriurético Atrial
/
Diurese
/
Natriurese
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1997
Tipo de documento:
Artigo
/
Congresso e conferência
/
Documento de projeto
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