Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of cabachol
Braz. j. med. biol. res
;
30(4): 493-6, Apr. 1997. graf
Artigo
em Inglês
| LILACS
| ID: lil-191387
ABSTRACT
We investigated the effects of losartan, an AT1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/l mul) into the LV blocked the pressor response induced by ANG II (12 ng/1 mul) and carbachol (2 nmol/ 1 mul). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 + 1 and 28 + 2 mmHg, respectively. Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 + 1 and 5 + 2 mmHg, respectively). The injection of ramipril (12 ng/ 1 mul) prior to carbachol blocked the pressor effect of carbachol to 7 + 3 mmHg. These results suggests an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Pressorreceptores
/
Sistema Renina-Angiotensina
/
Pressão Sanguínea
/
Carbacol
/
Receptores de Angiotensina
/
Inibidores da Enzima Conversora de Angiotensina
/
Ventrículos Cerebrais
/
Ramipril
/
Agonistas Colinérgicos
/
Imidazóis
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1997
Tipo de documento:
Artigo
/
Congresso e conferência
/
Documento de projeto
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