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Role of immune complexes from patients with different clinical forms of Schistosomiasis in the modulation of in vitro granuloma reaction
Mem. Inst. Oswaldo Cruz ; 92(5): 683-7, Sept.-Oct. 1997. graf
Artigo em Inglês | LILACS | ID: lil-194216
ABSTRACT
Schistosomiasis is a disease whose pathology is strongly related to the granulomatous reaction formed around parasite eggs trapped in host tissues. Studies have shown that the chronic intestinal form (INT) of the infection is associated with a variety of immunoregulatory mechanisms which lead to a diminished granulomatous reaction. Using an in vitro model of granuloma reaction, we show that immune complexes (IC) isolated from sera of INT patients are able to reduce granulomatous reaction developed by peripheral blood mononuclear cells (PBMC) from acute (AC), INT and hepatosplenic (HE) patients to soluble egg antigen (SEA)-conjugated polyacrylamide beads (PB-SEA). This inhibitory activity is also observed in cell proliferation assay of PBMC from INT and HE patients stimulated with SEA and adult worm antigen (SWAP). Furthermore, IC isolated from sera of patients with different clinical forms of the disease are also able to suppress INT patients PBMC reactivity. Therefore, our results show that circulating IC present in sera of patients with different clinical forms of schistosomiasis may down-regulate PBMC reactivity to parasite antigens resulting in a diminished granuloma reaction to parasite eggs.
Assuntos
Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Técnicas In Vitro / Granuloma / Complexo Antígeno-Anticorpo Limite: Humanos Idioma: Inglês Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: Medicina Tropical / Parasitologia Ano de publicação: 1997 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Técnicas In Vitro / Granuloma / Complexo Antígeno-Anticorpo Limite: Humanos Idioma: Inglês Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: Medicina Tropical / Parasitologia Ano de publicação: 1997 Tipo de documento: Artigo