Differential regulation of granuloma size and hepatic fibrosis in schistosome infections
Mem. Inst. Oswaldo Cruz
;
92(5): 689-92, Sept.-Oct. 1997. tab
Artigo
em Inglês
| LILACS
| ID: lil-194217
ABSTRACT
Granuloma size is the variable most frequently used to evaluate the immunopathogenesis of schistosome infections. However, hepatic fibrosis is at the least an equally relevant variable. Hepatic fibrosis and the size of circumoval granulomas are frequently dissociated in experimental murine Schistosoma mansoni and S. japonicum infections. Virtually nothing is known of the immunoregulation of schistosomal hepatic fibrosis. This review notes many of the studies which have found discrepancies in granuloma volume and hepatic fibrosis, attempts to put them in perspective and to evaluate methods of calculating changes in collagen synthesis or content.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Granuloma
/
Cirrose Hepática
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
1997
Tipo de documento:
Artigo
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