Genes and chromosomes of Leishmania infantum
Mem. Inst. Oswaldo Cruz
;
92(6): 853-8, Nov.-Dec. 1997. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-197227
ABSTRACT
During recent years, several Leishmania infantum genes have been cloned and characterized. Here, we have summarized the available information on the gene organization and expression in this protozoan parasite. From a comparative analysis, the following outstanding features were found to be common to most of the genes characterized tandemly organized genes with conserved coding regions and divergent untranslated regions, polycistronic transcription and post-transcriptional regulation of gene expression. The analysis of chromosomes of L. infantum by pulse-field electrophoresis showed the existence of both size and number polymorphisms such that each strain has a distinctive molecular karyotype. Despite this variability, highly conserved physical linkage groups exists among different strains of L. infantum and even among Old Word Leishmania species. Gene mapping on the L. infantum molecular karyotype evidenced a bias in chromosomal distribution of, at least, the evolutionary conserved genes.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Cromossomos
/
Leishmania infantum
/
Genes
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
1997
Tipo de documento:
Artigo
/
Congresso e conferência
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