Patients with hepatic cirrhosis: altered lymphocyte response to mitogens and its relation with plasmatic zinc, albumin and transferrin
Arch. med. res
;
25(1): 5-9, 1994. tab
Artigo
em Inglês
| LILACS
| ID: lil-198802
RESUMO
Patients with alchoholic hepatic cirrhosis have a higher predisposition to acquiring infections than healthy individuals, suggesting an alteration in the immune system. They also exhibit an important decrease in certain plasmatic constituents such as zinc, albumin, and transferrin which are involved in the normal immune response. The blastoid transformation of lymphocites stimulated in vitro with phytohemaglutinin M and P in patients with alcoholic hepatic cirrhosis was studied and the results were correlated with the plasmatic constitutents aforementioned. The rate of blastoid transformation was significantly lower (p<.001) in these patients when compared to the control group, but did not correlate directly with the concentration of zinc, albumin, transferrin or circulating globulins. Patients' plasma significantly inhibited the response of normal cells to stimulation with phytohemaglutinin and Concanavalin A; nevertheless, the blastoid transformation of lymphocytes in these patients was not restored to normal levels when incubated with control plasma
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Índice:
LILACS (Américas)
Assunto principal:
Interleucina-2
/
Sistema Imunitário
/
Cirrose Hepática
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Arch. med. res
Assunto da revista:
Medicina
Ano de publicação:
1994
Tipo de documento:
Artigo
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