Reduction of post-prandial motility by pinaverium bromide a calcium channel blocker acting selectively on the gastrointestinal tract in patients with irritable bowel syndrome
Acta gastroenterol. latinoam
;
27(4): 247-51, 1997. ilus
Artigo
em Inglês
| LILACS
| ID: lil-200084
RESUMO
Background:
Growing evidence points to irritable bowel syndrome physiologically as a disease of the enteric nervous system characterised by hypermotility. The aim of this study was to investigate the action of pinaverium bromide a calcium channel blocker acting selectively on the gastrointestinal tract on basal and post-prandial recto-anal motility of 40 irritable bowel syndrome patients in a random, double blind and placebo controlled trial.Methods:
Pinaverium bromide (50 mg) or placebo was taken orally t.i.d with food. Myoelectrical and mechanical activities of the rectum and the internal anal sphincter were recorded before treatment for 2 h in the fasting state and for an additional 2 h post-prandial.Results:
Post-prandial rectal spike amplitude and frequency as well as the spontaneous recto-anal inhibitory reflex frequency decreased after pinaverium bromide (P < 0.01) but not after placebo.Conclusions:
These results suggest that the calcium channel blockers acting selectively on the gastrointestinal tract may have a therapeutic role in patients with irritable bowel syndrome.
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Índice:
LILACS (Américas)
Assunto principal:
Reto
/
Bloqueadores dos Canais de Cálcio
/
Morfolinas
/
Doenças Funcionais do Colo
/
Motilidade Gastrointestinal
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Acta gastroenterol. latinoam
Assunto da revista:
Gastroenterologia
Ano de publicação:
1997
Tipo de documento:
Artigo
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