Application of various antioxidants in the treatment of influenza
Braz. j. med. biol. res
;
30(11): 1333-6, Nov. 1997. graf
Artigo
em Inglês
| LILACS
| ID: lil-201679
ABSTRACT
We determined the effect of the antioxidants superoxide dismutase, desferrioxamine and allopurinol on the survival of male CBA mice infected intranasally with 2-5 LD50 lung influenza virus A/Aichi/2/68. Survival for at least 20 days was observed for 45 percent of the mice that received 1000 U/day superoxide dismutase prepared from red blood cells on days 5,6,7 and 8 after infection, and 75 percent survival was observed for mice that received the same dose on days 4,5,6,7 and 8. Desferrioxamine, 25 mg/kg per day and 100 mg/kg per day injected subcutaneously, resulted in survival rates of 5 and 0 percent, respectively, compared to 10 percent survival observed for saline-injected controls. Allopurinol at doses of 5 to 50 mg/kg per day had no effect on mouse survival. These data demonstrate the efficacy of superoxide dismutase for the protection of mice against hemorrhagic lung edema. The ineffectiveness of allopurinol suggest that the xanthine oxidase system does not play a major role in hemorrhage or lung edema and that caution is necessary when desferrioxamine is administered during an acute inflammatory process accompanied by erythrocyte lysis.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Vírus da Influenza A
/
Superóxido Dismutase
/
Alopurinol
/
Desferroxamina
/
Influenza Humana
/
Antioxidantes
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1997
Tipo de documento:
Artigo
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