A new murine model of persistent lung eosinophilic inflammation
Mem. Inst. Oswaldo Cruz
; 92(supl.2): 215-8, Dec. 1997. tab, graf
Article
em En
| LILACS
| ID: lil-202036
Biblioteca responsável:
BR15.1
RESUMO
We summarize here the main characteristics of a novel model of pulmonary hypersensitivity. Mice were immunized with a subcutaneous implant of a fragment of heat solidified chicken egg white and 14 days later challenged with ovalbumin given either by aerosol or by intratracheal instillation. This procedure induces a persistent eosinophilic lung inflammation, a marked bone marrow eosinophilia, and Th2-type isotypic profile with histopathological findings that resemble human asthma. Further, this model is simple to perform, reproducible in different strains of mice, does not require adjuvants nor multiple boosters. Based on these characteristics we propose it as a suitable murine model of allergic eosinophilic lung inflammation.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Eosinofilia Pulmonar
/
Hipersensibilidade Respiratória
/
Asma
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
1997
Tipo de documento:
Article
/
Congress and conference