Comparison of mri-guided and ventriculography-based stereotactic surgery for Parkinson's disease

ABSTRACT

Stereotactic surgery for ParkinsonÝs disease can be performed using different neuroimaging methods. Ventriculography has been used to locate the coordinates of the structures close to the third ventricle. Although it has several potential disadvantages related to the intraventricular injection of iodine contrast, it is considered a precise method. Computed tomography and magnetic resonance imaging have been used in some centers. In order to compare their efficacy, 50 stereotactic thalamotomies for ParkinsonÝs disease were performed using either ventriculography (VE) (25) or magnetic resonance imaging (MRI) (25). In 14 out of 25 VE procedures, computed tomography (CT-scan) was also used and showed a significant mean difference of coordinate Y and Z. The clinical results employing either VE or MRI were similar, with 80 percent abolition of tremor in the VE group, and 84 percent in the MRI group, after a follow up period of at least 3 months. Another 12 percent of VE and 16 percent of MRI group showed significant improvement of tremor. Complication rate was 4 percent in both groups. MRI-guided stereotactic thalamotomy in Parkinson's disease has shown good clinical results, comparable to VE-guided stereotaxis.