Toxic, antimicrobial and hemagglutinating activities of the purple fluid of the sea hare Aplysia dactylomela Rang, 1828
Braz. j. med. biol. res
;
31(6): 785-91, jun. 1998. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-210967
ABSTRACT
The antimicrobial, hemagglutinating and toxic activities of the purple fluid of the sea hare Aplysia dactylomela are described. Intact or dialyzed purple fluid inhibited the growth of species of Gram-positive and Gram-negative bacteria and the action was not bactericidal but bacteriostatic. The active factor or factors were heat labile and sensitive to extreme pH values. The fluid preferentially agglutinated rabbit erythrocytes and, to a lesser extent, human blood cells, and this activity was inhibited by the glycoprotein fetuin, a fact suggesting the presence of a lectin. The fluid was also toxic to brine shrimp nauplii (LD 50 141.25 µg protein/ml) and to mice injected intraperitoneally (LD 50 201.8 ñ 8.6 mg protein/kg), in a dose-dependent fashion. These toxic activities were abolished when the fluid was heated. Taken together, the data suggest that the activities of the purple fluid are due primarily to substance(s) of a protein nature which may be involved in the chemical defense mechanism of this sea hare
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Aplysia
/
Bactérias
/
Líquidos Corporais
/
Hemaglutinação
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1998
Tipo de documento:
Artigo
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