Eosinophil-active chemokines: assessment of in vivo activity
Braz. j. med. biol. res
; 31(1): 19-24, Jan. 1998. ilus, tab
Article
em En
| LILACS
| ID: lil-212537
Biblioteca responsável:
BR1.1
ABSTRACT
The selective recruitment of eosinophils in tissue is a striking feature of allergic diseases. Recently, a family of chemoattractant molecules, namely chemokines, has been described which potently activates eosinophil function in vitro. We have developed a murine model of eosinophil recruitment to compare the relative potency and efficacy of chemokines in vivo. Of the chemokines tested, only eotaxin and MIP-1alpha induced significant accumulation of eosinophils in vivo, but eotaxin was more effective than MIP-1alpha. Chemokines, especially eotaxin acting via the CCR-3 receptor, may have a fundamental role in determining selective eosinophil recruitment in vivo.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Quimiocinas
/
Eosinófilos
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1998
Tipo de documento:
Article
/
Congress and conference