Cytokines in innate and acquired immunity to Trypanosoma cruzi infection
Braz. j. med. biol. res
; 31(1): 117-21, Jan. 1998.
Article
em En
| LILACS
| ID: lil-212546
Biblioteca responsável:
BR1.1
ABSTRACT
Reistance to Trypanosoma cruzi infections is critically dependent on cytokine-mediated activation of cell-mediated immune effector mechanisms. This review focuses on the role of IL-10, TNF-alpha, IFN-gamma and IL-12 in controlling T. cruzi replication by the innate and specific immune systems of the vertebrate host. A study performed on mice with disrupted recombinase-activating genes (RAG/KO), which lack T and B lymphocytes, revealed the importance of IL-12, IFN-gamma and TNF-alpha in the resistance against T. cruzi mediated by the innate immune system. In addition, data from experiments using IL-10 KO, RAG/KO and double RAG/IL-10 KO mice indicating an in vivo regulatory role of IL-10 in innate and T. cruzi-specific immunity are discussed.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Trypanosoma cruzi
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Tripanossomíase
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Citocinas
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Imunidade
/
Imunidade Inata
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1998
Tipo de documento:
Article
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Congress and conference