Meningiomas and hormonal receptors: immunohistochemical study in typical and non-typical tumors
Arq. neuropsiquiatr
;
56(2): 193-9, jun. 1998. ilus, tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-212809
RESUMO
The authors assessed 116 cases of meningiomas classified as typical, atypical and anaplastic and they used an immunohistochemical technique for estrogen and progesterone receptors attempting to determine if there is any difference between typical and non-typical tumors in relation to hormone receptors. The immunohistochemical technique to estrogen receptors was negative in all meningiomas studied. Progesterone receptors were detected in 58.3 percent of typical, and in 48.2 percent of non-typical meningiomas. This difference was not statistically significant. However, individually considering the criteria used for selection of non-typical tumours, those that concurrently displayed brain invasion and increased mitotic activity or necrosis, as well as the summation of those three features, were predominantly negative for progesterone receptors (respectively p=0.038; p=0.001; and p=0.044). The authors conclude that estrogen receptors were not present in meningiomas; that progesterone receptors in isolation are not enough to predict a higher tumoral malignancy but can be useful associated with other histological features.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Receptores de Progesterona
/
Receptores de Estrogênio
/
Neoplasias Meníngeas
/
Meningioma
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Aged80
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Arq. neuropsiquiatr
Assunto da revista:
Neurologia
/
Psiquiatria
Ano de publicação:
1998
Tipo de documento:
Artigo
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