Analogues and prodrugs, permanent useful alternatives to improve the effectiveness of natural anticancer compounds: Enhanced activity of slightly soluble salts of olivacine in L1210 leukemia
Ciênc. cult. (Säo Paulo)
;
49(5/6): 370-7, Sept.-Dec. 1997. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-214099
RESUMO
Several derivatives of well-known natural anticancer drugs have been synthesized and will continue to be, to overcome their delivering problems, or effectiveness. Characteristics such as poor solubility, metabolic inactivation, resistance development, rapid clearance or short half-life, adverse side effects like nausea, alopecia, anorexia are common undesirable limitations to their clinical use. Drug toxicity to less sensitive tumors as those in liver or brain is another aimed goal. Recent efforts to reverse undesirable physicochemical properties of well-established natural anticancer compounds are focused. Improved antitumor action of olivacine in L(1210) leukemia with slightly soluble halides with increased life span as well as "cured" animals was observed.
Buscar no Google
Índice:
LILACS (Américas)
Assunto principal:
Leucemia L1210
/
Elipticinas
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Revisões Sistemáticas Avaliadas
Limite:
Humanos
Idioma:
Inglês
Revista:
Ciênc. cult. (Säo Paulo)
Assunto da revista:
Ciência
Ano de publicação:
1997
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS