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Analogues and prodrugs, permanent useful alternatives to improve the effectiveness of natural anticancer compounds: Enhanced activity of slightly soluble salts of olivacine in L1210 leukemia
Ciênc. cult. (Säo Paulo) ; 49(5/6): 370-7, Sept.-Dec. 1997. tab, graf
Artigo em Inglês | LILACS | ID: lil-214099
RESUMO
Several derivatives of well-known natural anticancer drugs have been synthesized and will continue to be, to overcome their delivering problems, or effectiveness. Characteristics such as poor solubility, metabolic inactivation, resistance development, rapid clearance or short half-life, adverse side effects like nausea, alopecia, anorexia are common undesirable limitations to their clinical use. Drug toxicity to less sensitive tumors as those in liver or brain is another aimed goal. Recent efforts to reverse undesirable physicochemical properties of well-established natural anticancer compounds are focused. Improved antitumor action of olivacine in L(1210) leukemia with slightly soluble halides with increased life span as well as "cured" animals was observed.
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Índice: LILACS (Américas) Assunto principal: Leucemia L1210 / Elipticinas / Antineoplásicos Fitogênicos Tipo de estudo: Revisões Sistemáticas Avaliadas Limite: Humanos Idioma: Inglês Revista: Ciênc. cult. (Säo Paulo) Assunto da revista: Ciência Ano de publicação: 1997 Tipo de documento: Artigo

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Índice: LILACS (Américas) Assunto principal: Leucemia L1210 / Elipticinas / Antineoplásicos Fitogênicos Tipo de estudo: Revisões Sistemáticas Avaliadas Limite: Humanos Idioma: Inglês Revista: Ciênc. cult. (Säo Paulo) Assunto da revista: Ciência Ano de publicação: 1997 Tipo de documento: Artigo