Effects of methylene blue and indomethacin on sodium nitroprusside-induced relaxations of the guinea pig tracheal smooth muscle
Acta physiol. pharmacol. ther. latinoam
;
48(2): 83-7, 1998. graf
Artigo
em Inglês
| LILACS
| ID: lil-215285
ABSTRACT
The aim of the present investigation was to evaluate the potential modulatory effect of the guinea pig tracheal smooth muscle intrinsic tone on the relaxant responses to sodium nitroprusside and the effects of methylene blue on this response. Paired tracheal chains were mounted for isotonic contractions under 500 mg of tension in Krebs-Henseleit solution. The intrinsic modulatory tone was inhibited by indomethacin, in a concentration that did not have any effect over carbachol induced contractions. Sodium nitroprusside-induced relaxations were the same in the absence or presence of the modulatory tone. Methylene blue inhibited 50 per cent sodium nitroprusside-induced relaxations, in the presence or absence of the intrinsic system. This suggests that sodium nitroprusside-induced relaxations are mediated through guanylyl-cylase activation and that these are not under the modulation of the intrinsic prostaglandinergic tone.
Buscar no Google
Índice:
LILACS (Américas)
Assunto principal:
Traqueia
/
Indometacina
/
Inibidores de Ciclo-Oxigenase
/
Guanilato Ciclase
/
Azul de Metileno
/
Relaxamento Muscular
/
Músculo Liso
Limite:
Animais
Idioma:
Inglês
Revista:
Acta physiol. pharmacol. ther. latinoam
Assunto da revista:
Farmacologia
/
Fisiologia
/
Terapêutica
Ano de publicação:
1998
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS