Studies on the effect of ethanol on the Na+, and the Na+,K+ATPase activities of plasma membranes of rat kidney proximal tubular cells
Acta cient. venez
;
45(4): 281-6, 1994. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-216740
ABSTRACT
In the present work it was investigated the effect of 2 percent ethanol on the Na+ and on the Na+, K(+)-ATPase activities. The differential effect of the alcohol on the two ATPases (approximately 40 percent inhibition of the Na(+)-ATPase and approximately 10 percent inhibition of the Na+, K(+)-ATPase), is not due to a higher degree of denaturalization of the enzyme, nor to a faster effect of ethanol on the Na(+)-than on the Na+, K(+)-ATPase. Our results show that ethanol affects the selectivity of the Na+, K(+)-ATPase for Na+ and/or for K+, enhancing the Na+ affinity for the K+ sites, and/or reducing the K+ affinity for its own sites. This effect was not seen for the Na(+)-ATPase, indicating that 2 percent ethanol inhibits the two ATPases in a totally different way
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Índice:
LILACS (Américas)
Assunto principal:
Sódio
/
Membrana Celular
/
ATPase Trocadora de Sódio-Potássio
/
Etanol
/
Túbulos Renais Proximais
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cient. venez
Assunto da revista:
Ciência
Ano de publicação:
1994
Tipo de documento:
Artigo
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