Anterograde effects of a single electroconvulsive shock on inhibitory avoidance and on cued fear conditioning
Braz. j. med. biol. res
;
31(8): 1091-4, Aug. 1998. graf
Artigo
em Inglês
| LILACS
| ID: lil-216829
RESUMO
A single electroconvulsive shock (ECS) or a sham ECS was administered to male 3-4-month-old Wistar rats 1,2, and 4 h before training in an inhibitory avoidance test and in cued classical fear conditioning (measured by means of freezing time in a new environment). ECS impaired inhibitory avoidance at all times and, at 1 or 2 h before training, reduced freezing time before and after re-presentation of the ECS. These results are interpreted as a transient conditioned simulus (CS)-induced anxiolytic or analgesic effect lasting about 2 h after a single treatment, in addition to the known amnesic effect of the stimulus. This suggests that the effect of anterograde learning impairement is demonstrated unequivocally only when the analgesic/anxiolytic effect is over (about 4 h after ECS administration) and that this impairment of learning is selective, affecting inhibitory avoidance but not classical fear conditioning to a discrete stimulus.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Aprendizagem da Esquiva
/
Condicionamento Clássico
/
Eletrochoque
/
Medo
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1998
Tipo de documento:
Artigo
/
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