Effect of glucose-dependent insulinotropic polypeptide (GIP) on insulin response to glucose in acromegalics
Acta cient. venez
;
46(2): 89-96, 1995. graf
Artigo
em Inglês
| LILACS
| ID: lil-217134
RESUMO
The pancreatic beta-cell response to stimulation with glucose and GIP, single and combined, was studied in acromegalics and in normal subjects. Acromegalics had higher IRI and GIP basal values with glucose levels and glucose disposal in the normal range. Further, acromegalics showed a greater IRI response to glucose, GIP and glucose combined with GIP. The results suggested that high growth hormone levels cause a greater activity of the entero-insular axis both in the basal state and after meal ingestion, as mimicked by GIP infusion. From these and previous observations, it can be assumed that growth hormone induces a facilitation of the IRI response to metabolite substrates and hormones
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Índice:
LILACS (Américas)
Assunto principal:
Acromegalia
/
Polipeptídeo Inibidor Gástrico
/
Glucose
/
Insulina
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Acta cient. venez
Assunto da revista:
Ciência
Ano de publicação:
1995
Tipo de documento:
Artigo
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