Nitric oxide and peroxynitrite in lipid peroxidation
Medicina (B.Aires)
;
58(4): 361-6, 1998. graf
Artigo
em Inglês
| LILACS
| ID: lil-217515
RESUMO
Nitric oxide (.NO) can mediate tissue protective reactions during oxidant stress, as well as toxic and tissue prooxidant effect. Nitric oxide regulates critical lipid membrane and lipoprotein oxidation events, by 1) contributing to the formation of more potent secondary oxidants from superoxide (i.e. peroxynitrite) and 2) termination of lipid radicals to possibly less reactive secondary nitrogen-containing products (LONO, LOONO) which are in part organic peroxynitrites and are expected to be produced in vivo. Relative rates of production and steady state concentrations of superoxide and NO and cellular sites of production will profoundly influence expression of the differential oxidant injury-enhancing and protective effects of .NO. Full understanding of the physiological roles of .NO, coupled with detailed insight into .NO regulation of oxygen radical-dependent reactions, will yield a more rational basis for the use of .NO donors for therapeutic purposes.
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Índice:
LILACS (Américas)
Assunto principal:
Peroxidação de Lipídeos
/
Oxidantes
/
Nitratos
/
Óxido Nítrico
/
Antioxidantes
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Medicina (B.Aires)
Assunto da revista:
Medicina
Ano de publicação:
1998
Tipo de documento:
Artigo
/
Congresso e conferência
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