Experimental Trypanosoma rangeli infection in a mature model
Rev. biol. trop
;
44/45(3/1): 125-9, dic. 1996-mar. 1997. graf
Artigo
em Inglês
| LILACS
| ID: lil-219057
ABSTRACT
Trypanosoma rangeli experimental murine infections were performed in order to study parasitemias and anti-parasite antibody levels. Three groups of mice were used a) mice infected with metatrypomastigotes derived from infected bugs; b) mice which received four reinoculations of metatrypomastigotes and c) mice immunosuppressed with cyclophosphamide. The results showed that bloodstream parasites can be found from the first day post inoculation reaching a peak at day 5 or 7 and then start to decline. Parasites disappeared completely from the circulation after 20-25 days. However in the immunosuppressed group, parasites were found in blood up to 45 days post infection. The humoral immune response was monitored using an ELISA test and low levels of specific IgG and IgM unoglobulins were found. However the IgG titers were lower than the IgM. One could conclude that IgM was the predominant immunoglobulin isotype induced in a T. rangeli experimental infection because the highest titers were observed in the reinoculated group. IgM antibodies also showed the most prominent crossreactivities with T. cruzi antigens
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Índice:
LILACS (Américas)
Assunto principal:
Trypanosoma cruzi
/
Tripanossomíase
/
Anticorpos Antiprotozoários
Limite:
Animais
Idioma:
Inglês
Revista:
Rev. biol. trop
Assunto da revista:
Biologia
/
Medicina Tropical
Ano de publicação:
1997
Tipo de documento:
Artigo
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