Effects of chronic infusion of nerve growth factor (NGF) in rats with nucleus basalis magnocellularis lesion
La Habana; s.n; 1996. 4 p. tab, graf.
Não convencional
em Inglês
| LILACS
| ID: lil-223657
RESUMO
We attempted to evaluate the effects of bilaeral injection of ibotenic acid (IA) into the nucleus basalis magnocelluraris (rbm) of rats as well as the potential recovery mediated by the infusion of nerve growth factor (NGF). The lesion caused and impairment of learning and memory processes. Also, a severe depletion of choline acetyl transferase activity was detected in cortical areas. After the NGF administration, a significant reversion of these functional changes was observed. Thus, IA-lesioned rats might serve as a model for the evaluation of neurotrophic factors actions on basal forebrain damaged neurons
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Índice:
LILACS (Américas)
Assunto principal:
Ratos
/
Substância Inominada
/
Cognição
/
Ácido Ibotênico
/
Fatores de Crescimento Neural
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Ano de publicação:
1996
Tipo de documento:
Não convencional
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