Stressful stimulation of newborn mice increases the in vitro proliferative response in T cells from thymus
Arch. med. res
; Arch. med. res;28(3): 337-42, sept. 1997. ilus, tab
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| ID: lil-225237
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RESUMEN
The effects of prolonged stressful stimulaton on the in vitro proliferative response of thymic T cells and the thymic zinc concentration were investigated in newborn Balb/c mice. Animals were stressed y intraperitoneal injections with aliquots from a heat-killed staphyloccocal suspension over one month. The splenic T lymphocytes from the stressed animals showed a significant reduction in the in vitro response to cancanavalin A (Con-A) stimulation. However, an unexpected and significant increase in proliferative response was observed when thymic lymphocytes from stressed animals were stimulated with the same mitogen. The intrathymic zinc levels were regularly elevated in stressed mice, in contrast to those values obtained in the thymus from healthy control mice. These results suggest that neonatal stress can disrupt the intrathymic maturation and the selection of pre-T lymphocytes. The increment of the in vitro proliferative response of T cells from of thymus of stressed mice may be caused by proportionally higher amounts of intrathymic lymphoid suppopulations expressing a mature phenotype and functionality
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Índice:
LILACS
Assunto principal:
Estimulação Química
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Estresse Fisiológico
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Ativação Linfocitária
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Linfócitos T
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Concanavalina A
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Animais Recém-Nascidos
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Camundongos Endogâmicos BALB C
Limite:
Animals
Idioma:
En
Revista:
Arch. med. res
Assunto da revista:
MEDICINA
Ano de publicação:
1997
Tipo de documento:
Article