Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection
Braz. j. med. biol. res
;
32(2): 235-9, feb. 1999. ilus, tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-228266
ABSTRACT
Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease, does not synthesize sialic acid, but expresses a trans-sialidase (TS) that catalyzes the transfer of sialic acid from host glycoconjugates to the parasite surface. Here, we review studies that characterize the immune response to the catalytic domain of the enzyme in humans during Chagas' disease or in mice following immunization with the TS gene. In both cases, there are antibodies that strongly inhibit the enzymatic activity and generation of interferon-g-producing T cells
Texto completo:
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Índice:
LILACS (Américas)
Assunto principal:
Trypanosoma cruzi
/
Doença de Chagas
/
Vacinas de DNA
/
Neuraminidase
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1999
Tipo de documento:
Artigo
/
Congresso e conferência
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