Effect of policosanol on the hepatic cholesterol biosynthesis of normocholesterolemic rats
Biol. Res
;
29(2): 253-7, 1996.
Artigo
em Inglês
| LILACS
| ID: lil-228539
ABSTRACT
We have suggested previously, measuring 14C-acetate incorporation into free cholesterol, that oral administration of policosanol inhibits hepatic cholesterol biosynthesis in rats. Nevertheless, since acetate has limitations to study cholesterol synthesis in vivo, we now investigate rates of incorporation of labeled water into hepatic sterol after policosanol treatment. Absolute rates of incorporation of 3H-water in sterols were depressed by policosanol by about 20 percent, giving a more accurate degree of cholesterol biosynthesis inhibition in this species. Since policosanol did not inhibit labeled mevalonate incorporation into cholesterol in rat liver, we also studied the effect of policosanol on hydroxy-methylglutaryl-coenzyme A (HMG-CoA) reductase. Reductase activity assayed in microsomes treated with policosanol remained unchanged, suggesting that cholesterol synthesis is not inhibited by a direct action of policosanol on this enzyme
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Índice:
LILACS (Américas)
Assunto principal:
Colesterol
/
Álcoois Graxos
/
Hidroximetilglutaril-CoA Redutases
/
Fígado
/
Microssomos
/
Anticolesterolemiantes
Limite:
Animais
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
1996
Tipo de documento:
Artigo
País de afiliação:
Brasil
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