Trypanosoma cruzi topoisomerase II: a target enzyme for the chemotherapy of Chagas' disease? Cloning and characterization of its encoding gene
Biol. Res
;
26(1/2): 77-80, 1993.
Artigo
em Inglês
| LILACS
| ID: lil-228619
ABSTRACT
The study of Trypanosoma cruzi type II DNA-topoisomerase should provide new clues for the rational development of new drugs for the chemotherapy of Chagas' disease. This enzyme is very likely involved in the processes leading to T. cruzi replication and differentiation since both processes are blocked by bacterial type II DNA topoisomerase inhibitors. In this article, we review and discuss our recent data related to the cloning, sequencing, and expression of T. cruzi type II topoisomerase
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Índice:
LILACS (Américas)
Assunto principal:
Trypanosoma cruzi
/
Genes de Protozoários
/
DNA Topoisomerases Tipo II
Limite:
Animais
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
1993
Tipo de documento:
Artigo
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