Bacterial chemistry. VI. Biological activities and cytotoxicity of 1, 3-dihydro-2H-indol-2-one derivatives
Biol. Res
;
25(1): 21-5, 1992. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-228630
RESUMO
The biosynthetic pigment from Chromobacterium violaceum BB-78, 1,3-dihydro-2H-indol-2-one and its derivatives exhibit biological activities such as antimicrobial action, low hemolytic effects on red blood cells and in vitro trypanocide activity. A relatively high cytotoxicity on V-79 hamster fibroblast cells of the biosynthetic pigment was found, although with the methylol derivative the toxicity was almost eliminated. The methylol derivative exhibited similar toxicity as Nifurtimox, a known, commercial trypanocide compound
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Índice:
LILACS (Américas)
Assunto principal:
Pigmentos Biológicos
/
Chromobacterium
/
Hemólise
/
Indóis
/
Antibacterianos
Limite:
Animais
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
1992
Tipo de documento:
Artigo
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