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Concurrent effect of morphine on thalamic nociceptive neurons and medullary on and off cells
Acta cient. venez ; 44(4): 221-4, 1993. ilus, tab
Artigo em Inglês | LILACS | ID: lil-230632
ABSTRACT
On-and off-cells of the rostral ventromedial medulla project to the spinal cord, where off-cells are postulated to inhibit, and on-cell facilitate, nociceptive transmission. In the present experiments, unitary recordings were made from ventrobasal (VB) thalamic neurons and, simultaneously, on-or off-cells in lighhtly anesthetized rats. When the tail was heated (45-55ºC) off-cells stopped firing (pause) and on-cells began to fire (burst) 0.5-06s before VB neurons responded to the tail stimulus. Administration of morphine sulfate (2mg/kg i.v) concurrently prevented the off-cell pause, the on-cell burts an the VB neuronal response. Naloxone (1mg/kg i.v) recersed these effects. The results are consistent with the notion that prevention of the off-cell pause and the on-cell burst by morphine is responsible for the lack of nociceptive information flow towards the thalamus
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Índice: LILACS (Américas) Assunto principal: Lúpus Eritematoso Sistêmico / Mielite Transversa Limite: Adolescente / Feminino / Humanos Idioma: Inglês Revista: Acta cient. venez Assunto da revista: Ciência Ano de publicação: 1993 Tipo de documento: Artigo

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Índice: LILACS (Américas) Assunto principal: Lúpus Eritematoso Sistêmico / Mielite Transversa Limite: Adolescente / Feminino / Humanos Idioma: Inglês Revista: Acta cient. venez Assunto da revista: Ciência Ano de publicação: 1993 Tipo de documento: Artigo