Superantígenos y su rol en las enfermedades infecciosas / The role of superantigens in infectious diseases
Rev. méd. Chile
;
126(7): 846-54, jul. 1998. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: lil-231528
RESUMO
Exogenous antigens are presented to T lymphocytes through mechanisms that ensure high recognition specificity. Recently described superantigens in contrast to conventional antigens are particles that follow a different processing and presentation route not binding to a specific region of T lymphocyte receptors. These particles bind to a large number of T lymphocytes, generating a disproportionate and non-specific immune response. Two types of superantigens have been described. Endogenous superantigens, transported in the host genoma, have been involved in clonal depletion and immunological tolerance phenomena. Exogenous superantigens, mainly bacterial toxins, have been involved in several diseases. There is evidence that these antigens participate in diseases such as Kawasaki disease, toxic shock caused by Staphylococcus aureus, rheumatoid arthritis, HIV infection and Streptococcus pyogenes infections
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Doenças Transmissíveis
/
Superantígenos
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1998
Tipo de documento:
Artigo
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