Senescent erythrocytes: modification of rheologic properties, antigenic expression and interaction with monocytes
Medicina (B.Aires)
; 59(1): 33-7, 1999. tab, graf
Article
em En
| LILACS
| ID: lil-231907
Biblioteca responsável:
BR1.1
ABSTRACT
Human erythrocytes have a well-defined lifespan of 120 days. Their eventual removal from circulation is a complex process affected by many cellular parameters, making them susceptible to sequestration in the spleen and other organs. The purpose of this study was to investigate putative changes in rheologic properties, antigenic expression and interaction with monocytes of senescent erythrocytes (SE). SE and young erythrocyte (YE) fractions were obtained by differential centrifugation from 20 healthy donor blood samples. Membrane rheomechanic properties (by difractometric method), ABO and MN antigens reactivity and erythrophagocytosis by peripheral monocytes were investigated in each fractions. SE showed a little decrease in the deformability index and an increase of both membrane elastic modulus and surface viscosity. The studies performed indicate a decreased expression in the antigens of both blood group systems studied (p < 0.01) and an increased rate of erythrophagocytosis by monocytes in SE compared to YE (p < 0.01). The significant modifications in the biomechanic properties of senescent red blood cell membrane and the loss antigenic expression could lead to physiological phagocytosis.
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Índice:
LILACS
Assunto principal:
Reologia
/
Monócitos
/
Comunicação Celular
/
Envelhecimento Eritrocítico
Limite:
Humans
Idioma:
En
Revista:
Medicina (B.Aires)
Assunto da revista:
MEDICINA
Ano de publicação:
1999
Tipo de documento:
Article