Developed pressure data may provide misinformation when used alone to evaluate systolic function in isovolumetric left ventricle preparations
Braz. j. med. biol. res
;
32(6): 773-6, Jun. 1999. tab, ilus
Artigo
em Inglês
| LILACS
| ID: lil-233711
RESUMO
We report data showing that developed pressure (DPmax) may lead to opposite conclusion with respect to maximal developed circumferential wall stress (max) when used to assess contractile function in left ventricle isovolumic preparations. Isovolumetric left ventricle preparations of rats with cardiac hypertrophy (H; N = 10) induced by isoproterenol administration showed higher DPmax (174 + ou - 14 mmHg) than control (C; N = 8) animals (155 + ou - 12 mmHg) or rats with regression (R; N = 8) of hypertrophy (144 + ouy - 11 mmHg). In contrast, the estimated max for C (145 + ou - 26 kdynes/cm2) and R (133 + ou - 17 kdynes/cm2) was higher than for H (110 + ou - 13 kdynes/cm2). According to Laplace's law, the opposite results of DPmax and max may depend on the increased mass/volume left ventricle ratio of the hypertrophied hearts, which favored pressure generation. These results clearly show that DPmax should be used with caution to analyze systolic function.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Determinação da Pressão Arterial
/
Função Ventricular Esquerda
/
Cardiomegalia
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1999
Tipo de documento:
Artigo
/
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