Mechanisms of cell transformation induced by polyomavirus
Braz. j. med. biol. res
;
32(7): 861-5, July 1999.
Artigo
em Inglês
| LILACS
| ID: lil-234892
RESUMO
Polyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis. LT is associated with cell immortalization, whereas MT plays an essential role in cell transformation by binding to and activating several cytoplasmic proteins that participate in growth factor-induced mitogenic signal transduction to the nucleus. The use of different MT mutants has led to the identification of MT-binding proteins as well as analysis of their importance during cell transformation. Studying the molecular mechanisms of cell transformation by MT has contributed to a better understanding of cell cycle regulation and growth control
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Transdução de Sinais
/
Transformação Celular Neoplásica
/
Antígenos Transformantes de Poliomavirus
/
Polyomavirus
/
Infecções por Papillomavirus
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1999
Tipo de documento:
Artigo
/
Congresso e conferência
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