Genetics, drugs and environmental factors in Parkinson's disease: a case-control study
Arq. neuropsiquiatr
;
57(2B): 347-55, jun. 1999. tab
Artigo
em Inglês
| LILACS
| ID: lil-236058
RESUMO
A case-control study of Parkinsonïs disease (PD) was conducted in the city of Rio de Janeiro based on the asumption that neurotoxins with secondary parkinsonian action may be related to the development of Parkinsonïs disease. Ninety-two subjects with PD and 110 controls were queried through a questionnaire in order to investigate possible risk factors for the disease. The following factors were studied herbicides/pesticides, exposure to chemicals, ingestion of drugs with secondary PD effects, rural life, water well source, family history, cranial trauma and cigarette smoking. Study of mentioned factors was archieved through univariate, stratified and multivariate analyses. Univariate and multivariate analyses demonstrated that PD was positively associated with family history (OR=14.5; CI-2,98 - 91.38), with the use of drugs with secondary PD action (OR=11.01; CI=3.41 - 39.41) and with exposure to chemical agents (OR= 5.87; CI=1.48 - 27.23). PD was found to be inversely associated with cigarette smoking (OR=0.39; IC=0.16 - 0.95). Stratified analysis only confirmed family history and drug use, besides demonstrating that cigarette consumption could be a protection factor, when aforementioned factors were involved. This study might be a warning as to the cares that need to be taken regarding drug use and occupational exposure to chemical agents, as both types of substances present secondary PD action.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Doença de Parkinson
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Arq. neuropsiquiatr
Assunto da revista:
Neurologia
/
Psiquiatria
Ano de publicação:
1999
Tipo de documento:
Artigo
País de afiliação:
Brasil
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