Influence of antibiotics on the mechanical responses of guinea-pig ileum to acetycholine and histamine

ABSTRACT

The side effects of antibiotics have been extensively described during the last decades, however, their role on digestive motility must be better investigated. Following a line research, the influence of penicillin, chloranfenicol tetracycline and gentamicine on longitudinal snooth muscle response to acetylcholine and histamine were studied on guinea-pig ileum. There were no differences between the responses before and after the addition of each antibiotic. Further investigations must be performed in order to find a possible influence of antibiotics on digestive motility.