Risk factors for HTLV-I mother to child transmission: influence of genetic markers
Braz. j. infect. dis
;
2(3): 135-42, Jun. 1998. tab
Artigo
em Inglês
| LILACS
| ID: lil-243409
RESUMO
This study was designed to evaluate the influence of genetic markers on the seropositivity of offspring of HTLV-I positive mothers in Tumaco, Colombia, an endemic area for HTLV-I infection and a site where there exists a racially mixed population of Black and Caucasian ancestors. 33 HTLV-I seropositive women with at least one offspring were studied. A total of 111 offspring were tested using hemaglutination-inhibition for testing sera for the allotypic markers G1m (1,2,3, 17) and G3m (5, 6, 13, 21). Potential risk factors such as mother's age at child's birth, mother's age at the time of the study, breastfeeding months, TSP vs. asymptomatic HTLV-I carrier, sibship's size, children's age and sex, were not found to be associated with mother to child transmission. Mother's Negroid genetic marker genotype (1, 17, 5, 13/1, 17, 5, ñ 13) was margininally associated with mother to child transmission of HTLV-I (P=0.057; OR=11.97; CI=0.92-155.96).
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Índice:
LILACS (Américas)
Assunto principal:
Sorodiagnóstico da AIDS
/
Vírus Linfotrópico T Tipo 1 Humano
/
Infecções por HTLV-I
/
Marcadores Genéticos
/
Fatores de Risco
/
Transmissão Vertical de Doenças Infecciosas
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
País/Região como assunto:
América do Sul
/
Colômbia
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
1998
Tipo de documento:
Artigo
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