Lack of association between parenchymal neurocysticercosis and HLA Class I and Class II antigens
Genet. mol. biol
;
22(1): 7-11, Mar. 1999. tab
Artigo
em Inglês
| LILACS
| ID: lil-243510
RESUMO
Neurocysticercosis, caused by encysted larvae of the tapeworm Taenia solium, is the most common infection of the central nervous system and a major public health problem in many countries. Prevalence in the region of Curitiba, located in the southern Brazilian State of Paraná, is one of the highest in the world. The genetics of host susceptibility to neurocysticercosis (NCC) is still obscure. To investigate if major histocompatibility complex (MHC) genes influence individual susceptibility to NCC, we performed a case-control association analysis. Fifty-two Caucasoid patients and 149 matched controls were typed for antigens of the HLA-A, B, C, DR and DQ loci. All patients had computerized tomography and clinical features compatible with parenchymal NCC. Indirect immunofluorescence of cerebrospinal fluid showed that 19 (37 per cent) of the patients presented anti-cysticercus antibodies at titers > or = 1:10. Frequencies of HLA specificities in the whole group of patients and in the subgroup with antibodies in cerebrospinal fluid were compared to those of the control group. No significant difference was found. These results do not support the hypothesis of HLA gene participation in susceptibility to parenchymal neurocysticercosis.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Genes MHC Classe I
/
Genes MHC da Classe II
/
Neurocisticercose
/
Predisposição Genética para Doença
/
Antígenos HLA
Tipo de estudo:
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Genet. mol. biol
Assunto da revista:
Genética
Ano de publicação:
1999
Tipo de documento:
Artigo
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