Caracterización cinética de la respuesta de secreción salival producida por ácido cítrico: diferencias con pilocarpina / Kinetic assessment of salivary secretory response to citric acid, as compared with pilocarpine
Rev. méd. Chile
;
126(11): 1330-7, nov. 1998. graf
Artigo
em Espanhol
| LILACS
| ID: lil-243725
RESUMO
Background:
Induction of salivation is becoming increasingly popular in the assessment of salivary gland status. Various mechanical or pharmacological procedures are empirically used to produce salivation. Oral stimulation by citric acid (AC) is by far the most used sialagogue procedure.Aim:
To characterize the salivary secretory response to AC solutions applied to the dorsolateral tongue surfaces. Subjects andmethods:
Young healthy women from the upper levels of a medical career (n=19) participated as volunteers. Salivary volume and UV-absorbing organic material in saliva from single subjects were measured after various protocols of topical stimulation by AC.Results:
After a single stimulation by 1-8 percent AC the salivary flow rate peaked before 30 seconds and recovered the basal level earlier than 2 minutes. Repetitive stimulations at 30-sec intervals kept the flow rate at a maximum. After suspending these stimulations, basal flow rate was recovered before 2 minutes. Repetitive AC-stimulations at 8-min intervals produced a series of identical and independent secretory responses. The concentration of organic material in saliva remained unaltered after the various modes of stimulation. Thus, the profile of organic material secretion was always a direct expression of changes in salivary flow rate. In contrast to AC, the oral administration of the cholinergic agonist pilocarpine (PIL) produced a two-wave salivary response that as a whole lasted for about 30 minutes. In this case the volume and the amount of organic material were at least 10-fold the ones secreted in response to AC.Conclusions:
AC provoked a rapid and short-lived salivary response that differs markedly from the one produced by other secretagogues, like pilocarpine
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Índice:
LILACS (Américas)
Assunto principal:
Pilocarpina
/
Saliva
/
Glândulas Salivares
/
Salivação
/
Ácido Cítrico
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1998
Tipo de documento:
Artigo
/
Documento de projeto
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