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Utilidad de la determinación del factor de crecimiento insulino-simil tipo I (IGF-I) y de su proteína ligante tipo 3 (IGFBP-3) en el diagnóstico de la deficiencia de hormona de crecimiento en niños / Usefulness of the measurement of insulin-like growth factor 1 (IGF-I) and IGF-1 binding protein-3 (IGFBP-3) for the diagnosis of growth hormone (GH) deficiency in children
Codner D., Ethel; Méricq G., Verónica; Ugarte P., Francisca; Iñiguez Vila, Germán; Espinoza F., Marcela; Avila A., Alejandra; Salazar C., Teresa; Cassorla G., Fernando; García Bruce, Hernán.
  • Codner D., Ethel; s.af
  • Méricq G., Verónica; s.af
  • Ugarte P., Francisca; s.af
  • Iñiguez Vila, Germán; s.af
  • Espinoza F., Marcela; s.af
  • Avila A., Alejandra; s.af
  • Salazar C., Teresa; s.af
  • Cassorla G., Fernando; s.af
  • García Bruce, Hernán; Universidad de Chile. Instituto de Investigaciones Materno Infantil.
Rev. méd. Chile ; 127(7): 807-13, jul. 1999. tab, graf
Artigo em Espanhol | LILACS | ID: lil-245386
RESUMEN

Background:

The diagnosis of GH deficiency (GHD) is based upon the results of GH stimulation tests, which have several drawbacks.

Aim:

To evaluate the usefulness of IGF-1 and IGFBP-3 for the diagnosis of GHD in prepuberal children. Material and

methods:

We measured IGF-I and IGFBP-3 in three group of

subjects:

I. GHD (n24), height <-2SD for age (Z score, average ñ SD -4.2 ñ 1.2), growth velocity 7 ng/ml (15.3 ñ 6.9 ng/ml), y III. Normal school children (n35) with normal heights (-0.17 ñ 0.12 SD) were studied as controls.

Results:

IGF-1 and IGFBP-3 were significantly lower in GHD than in NGHD and controls (p <0.001), and in NGHD than in C (p <0.001). We defined the normal range of both proteins as ñ 2 SD of the mean of the control group. Using this criteria, IGF-I was low in 21/24 GHD, and in 12/32 NGHD. IGFBP-3 was low in 22/24 GHD, and in 6/32 NGHD. Only 1 GHD patient had both exams in the normal range, suggesting that he is probably NGHD. 4/32 of the NGHD had both exams below normal range, suggesting that they are probably GHD.

Conclusions:

IGF-1 and IGFBP-3 are important tools for the diagnosis of GHD
Assuntos
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Índice: LILACS (Américas) Assunto principal: Fator de Crescimento Insulin-Like I / Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina / Hormônio do Crescimento Humano Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo observacional Limite: Feminino / Humanos / Masculino Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 1999 Tipo de documento: Artigo / Documento de projeto

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Índice: LILACS (Américas) Assunto principal: Fator de Crescimento Insulin-Like I / Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina / Hormônio do Crescimento Humano Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo observacional Limite: Feminino / Humanos / Masculino Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 1999 Tipo de documento: Artigo / Documento de projeto