Utilidad de la determinación del factor de crecimiento insulino-simil tipo I (IGF-I) y de su proteína ligante tipo 3 (IGFBP-3) en el diagnóstico de la deficiencia de hormona de crecimiento en niños / Usefulness of the measurement of insulin-like growth factor 1 (IGF-I) and IGF-1 binding protein-3 (IGFBP-3) for the diagnosis of growth hormone (GH) deficiency in children
Rev. méd. Chile
;
127(7): 807-13, jul. 1999. tab, graf
Artigo
em Espanhol
| LILACS
| ID: lil-245386
RESUMEN
Background:
The diagnosis of GH deficiency (GHD) is based upon the results of GH stimulation tests, which have several drawbacks.Aim:
To evaluate the usefulness of IGF-1 and IGFBP-3 for the diagnosis of GHD in prepuberal children. Material andmethods:
We measured IGF-I and IGFBP-3 in three group ofsubjects:
I. GHD (n24), height <-2SD for age (Z score, average ñ SD -4.2 ñ 1.2), growth velocityResults:
IGF-1 and IGFBP-3 were significantly lower in GHD than in NGHD and controls (p <0.001), and in NGHD than in C (p <0.001). We defined the normal range of both proteins as ñ 2 SD of the mean of the control group. Using this criteria, IGF-I was low in 21/24 GHD, and in 12/32 NGHD. IGFBP-3 was low in 22/24 GHD, and in 6/32 NGHD. Only 1 GHD patient had both exams in the normal range, suggesting that he is probably NGHD. 4/32 of the NGHD had both exams below normal range, suggesting that they are probably GHD.Conclusions:
IGF-1 and IGFBP-3 are important tools for the diagnosis of GHD
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Índice:
LILACS (Américas)
Assunto principal:
Fator de Crescimento Insulin-Like I
/
Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina
/
Hormônio do Crescimento Humano
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo observacional
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1999
Tipo de documento:
Artigo
/
Documento de projeto
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