Renal function in the diabetic pregnant rats
Acta physiol. pharmacol. ther. latinoam
; 49(2): 65-70, 1999. graf
Article
em En
| LILACS
| ID: lil-245920
Biblioteca responsável:
BR1.1
RESUMO
Diabetic nephropathy is associated with increased urinary albumin and reduce kallikrein excretion. Increased activity of the renal kallikrein-kinin system has been suggested as one of the possible mechanisms underlying diabetic hyperfiltration. The present study shown that kallikrein-kinin system is progressively increased in the diabetic-pregnant rats at 7, 14, 21 days; 48 and 7 days after pregnancy (P<0.05 vs Control). However, this increase during diabetic pregnancy did not reached the levels of control pregnancy. On the other hand albumin excretion shown a significant and progressive renal damage in the diabetic state. These findings suggest that the diabetic pregnancy could impair the renal hemodynamic, but, on the other side could modulate the vasodilatador system at pregnancy in the attempt protect the fetus.
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Índice:
LILACS
Assunto principal:
Gravidez em Diabéticas
/
Calicreínas
/
Diabetes Mellitus Experimental
/
Nefropatias Diabéticas
Limite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Acta physiol. pharmacol. ther. latinoam
Assunto da revista:
FARMACOLOGIA
/
FISIOLOGIA
/
TERAPEUTICA
Ano de publicação:
1999
Tipo de documento:
Article