Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenase
Braz. j. med. biol. res
;
32(11): 1345-52, Nov. 1999.
Artigo
em Inglês
| LILACS
| ID: lil-248428
RESUMO
Cardiac surgery involving ischemic arrest and extracorporeal circulation is often associated with alterations in vascular reactivity and permeability due to changes in the expression and activity of isoforms of nitric oxide synthase and cyclooxygenase. These inflammatory changes may manifest as systemic hypotension, coronary spasm or contraction, myocardial failure, and dysfunction of the lungs, gut, brain and other organs. In addition, endothelial dysfunction may increase the occurrence of late cardiac events such as graft thrombosis and myocardial infarction. These vascular changes may lead to increased mortality and morbidity and markedly lengthen the time of hospitalization and cost of cardiac surgery. Developing a better understanding of the vascular changes operating through nitric oxide synthase and cyclooxygenase may improve the care and help decrease the cost of cardiovascular operations.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Ponte Cardiopulmonar
/
Prostaglandina-Endoperóxido Sintases
/
Isquemia Miocárdica
/
Óxido Nítrico Sintase
/
Vasos Coronários
/
Parada Cardíaca Induzida
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1999
Tipo de documento:
Artigo
/
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