Transforming growth factor beta activity in urine of patients with type 2 diabetes and diabetic nephropathy
Braz. j. med. biol. res
;
32(12): 1525-8, Dec. 1999. graf
Artigo
em Inglês
| LILACS
| ID: lil-249378
ABSTRACT
Diabetic nephropathy (DN) is characterized structurally by progressive mesangial deposition of extracellular matrix (ECM). Transforming growth factor-ß (TGF-ß) is considered to be one of the major cytokines involved in the regulation of ECM synthesis and degradation. Several studies suggest that an increase in urinary TGF-ß levels may reflect an enhanced production of this polypeptide by the kidney cells. We evaluated TGF-ß in occasional urine samples from 14 normal individuals and 23 patients with type 2 diabetes (13 with persistent proteinuria >500 mg/24 h, DN, 6 with microalbuminuria, DMMA, and 4 with normal urinary albumin excretion, DMN) by enzyme immunoassay. An increase in the rate of urinary TGF-ß excretion (pg/mg UCreat.) was observed in patients with DN (296.07 + or - 330.77) (P<0.001) compared to normal individuals (17.04 + or - 18.56) (Kruskal-Wallis nonparametric analysis of variance); however, this increase was not observed in patients with DMMA (25.13 + or - 11.30) or in DMN (18.16 + or - 11.82). There was a positive correlation between the rate of urinary TGF-ß excretion and proteinuria (r = 0.70, a = 0.05) (Pearson's analysis), one of the parameters of disease progression.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Fator de Crescimento Transformador beta
/
Diabetes Mellitus Tipo 2
/
Nefropatias Diabéticas
Limite:
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1999
Tipo de documento:
Artigo
/
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