Studies on the effectiveness of diarylheptanoids derivatives against Leishmania amazonensis
Mem. Inst. Oswaldo Cruz
;
94(6): 791-4, Nov.-Dec. 1999.
Artigo
em Inglês
| LILACS
| ID: lil-251341
ABSTRACT
In a previous work we demonstrated that diarylheptanoids extracted from Centrolobium sclerophyllum are very active against Leishmania amazonensis promastigotes. In order to continue our studies with these class of compounds, we decided to evaluate the activity of several diarylheptanoids derived from curcumin (diferuloyl methane) against the extracellular form (promastigotes) of L. amazonensis. Furthermore, an experiment against the intracellular form of the parasite (amastigotes) was carried out, comparing the most active compound among the curcumin derivatives (the methylcurcumin) with des-O-methylcentrolobine, the most active diarylheptanoid derived from C. sclerophyllum
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Anti-Inflamatórios não Esteroides
/
Curcumina
/
Leishmania
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
1999
Tipo de documento:
Artigo
País de afiliação:
Brasil
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